Studies on free erythrocyte protoporphyrin, plasma copper, and plasma iron in normal and in pyridoxine-deficient swine.
نویسندگان
چکیده
Previous communications from this laboratory (l-7) have demonstrated that swine maintained on a highly purified diet deficient in pyridoxine develop a severe anemia which is characterized by microcytosis, slight hypochromia, and an increase in polychromatophilia, reticulocytes, and nucleated red cells in the blood. There is a marked hyperferremia, normoblastic bone marrow hyperplasia, myelin degeneration in the peripheral nerves, and hemosiderosis in the liver, spleen, and bone marrow. Certain alterations in tryptophan met.abolism, namely an increased excretion of xanthurenic acid, kynurenine, and urorosein, occur. The administration of pyridoxine is followed by a sharp reticulocyte response, mobilization of iron froin the tissues, and rapid regeneration of blood with restoration of the normal size of erythrocytes. The anemia fails to respond to the administration of either iron or pursed liver extract. Appropriate studies have failed to reveal evidence that the anemia is due to increased blood destruction and it has been concluded that it is due to a disturbance in erythropoiesis. The nature of this disturbance has not, however, been discovered. The purpose of this report is to present data concerning certain aspects of the metabolism of porphyrin, copper, and iron in pyridoxine-deficient swine, which were gathered in an attempt to elucidate the mechanism by which a deficiency of pyridoxine produces anemia. The literature dealing with the relation of pyridoxine to erythropoiesis has recently been reviewed (8).
منابع مشابه
The Kinetics of Iron Metabolism in Swine with Various Experimentally Induced Anemias
Ferrokinetic studies were performed on 3 swine given phenylhydrazine, 3 swine deficient in pyridoxine, and 3 swine deficient in pteroylglutamic acid. Body surface radioactivity was measured in 2 pteroylglutamic acid-deficient animals. In the animals given phenylhydrazine, the mean erythrocyte survival time was 5 days. The plasma iron turnover rate was increased about fourfold, and the rate of e...
متن کاملStudies on free erythrocyte protoporphyrin, plasma iron and plasma copper in normal and anemic subjects.
T HE VARIOUS anemias have been studied and classified clinically, morphologically, therapeutically and to a less extent etiologically, but comparatively few chemical studies have been made. Investigation of the chemical changes accompanying the various types of anemia offers a new approach to their study and gives rise to the hope that as the specific defects are elucidated their correction wil...
متن کاملStudies on Copper Metabolism. Xix
Ferrokinetic studies were performed in three copper-deficient swine and the results have been compared with similar studies in 18 normal pigs. The mean value for the plasma iron turnover rate in the deficient swine was 1.76 mg./kg. day; for the red cell iron incorporation rate, 1.24 mg./kg. day; for the red cell iron turnover rate, 1.18 mg./kg. day; for the red cell life span, 13 days. Correspo...
متن کاملStudies on Free Erythrocyte Protoporphyrin, Serum Iron, Serum Iron-binding Capacity and Plasma Copper during Normal Pregnancy.
متن کامل
Iron metabolism in copper-deficient swine.
The way in which iron is handled by the duodenal mucosa, the reticuloendothelial system, the hepatic parenchymal cell, and the normoblast was investigated in copper-deficient swine.Copper-deficient swine failed to absorb dietary iron at the normal rate. Increased amounts of stainable iron were observed in fixed sections of duodenum from such animals. When (59)iron was administered orally, the m...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 172 2 شماره
صفحات -
تاریخ انتشار 1948